Figure 7 | Cell Death & Disease

Figure 7

From: miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer

Figure 7

Inhibition of miR-148a-3p expression partially rescues Si-ERBB3-induced suppression of cell proliferation and EMT. (a and b) Co-transfection of miR-148a-3p-Inh attenuated the ERBB3 expression inhibited by Si-ERBB3 at the mRNA and protein level in both bladder cancer cell lines. Similar p-AKT protein expression pattern was also observed. (c–e) Transfection of miR-148a-3p-Inh partially but significantly rescued the Si-ERBB3-induced inhibition of cell proliferation, cell cycle and motility in T24 cell line. Error bars represent the S.E. obtained from three independent experiments; *P<0.05. Scale bar=100 μm

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