Table 2 Univariate and multivariate analyses of predictors of overall survival in bladder cancer patients

From: miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer

Variables

Death

  

Univariable analysis

Multivariable analysis

 

Yes

No

N

%

P -value a

HR (95% CI)

P -value b

Age

 <69

13

13

26

44.8

0.963

  

 ≥69

16

16

32

55.2

   

Gender

 Male

23

26

49

84.5

0.298

4.447 (1.350–14.645)

0.014

 Female

6

3

9

15.5

   

Tumor grade

 Low

2

1

3

5.3

0.752

  

 High

27

27

54

94.7

   

Tumor stage

 I–II

9

19

28

50.0

0.002

6.083 (2.141–17.284)

0.001

 III–IV

19

9

28

50.0

   

Lymph node invasion

 Yes

6

1

7

16.3

0.005

  

 No

15

21

36

83.7

   

ERBB3

 High

27

19

46

79.3

0.026

4.575 (1.042–20.084)

0.044

 Low

2

10

12

20.7

   

DNMT1

 High

15

11

26

44.8

0.432

  

 Low

14

18

32

55.2

   

miR-148-3p

 High

15

17

32

55.2

0.659

  

 Low

14

12

26

44.8

   
  1. Abbreviations: 95% CI, 95% confidence interval; HR, hazard risk ratio
  2. aStatistical analysis was conducted by Kaplan–Meier method (log-rank test)
  3. bCox proportional hazards regression
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