Figure 1 | Cell Death & Disease

Figure 1

From: Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

Figure 1

3-MA markedly inhibited the development of atherosclerotic lesion in ApoE−/− mice fed with HFD. (a) Representative images of Oil Red O-stained plaque burden (red) in aortas from control mice (6 mice from 14 control mice) and 3-MA-treated mice (6 mice from the 16 3-MA-treated mice). Data are percentage ORO-stained plaque areas in the entire aorta and regions (aortic arch, thoracic aorta and abdominal aorta). (b and c) Representative hematoxylin and eosin (H&E) staining and Oil Red O staining of cross-sections of aortic root in control mice (n=14) and 3-MA-treated mice (n=16). Scale bar, 200 μm. Data are mean±S.D. *P<0.05, **P<0.01, ***P<0.001, unpaired two-tailed Student’s t-test

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