Figure 2 | Cell Death & Disease

Figure 2

From: Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE−/− mice by modulating autophagy, foam cell formation and immune-negative molecules

Figure 2

3-MA application improved the stability of plaque. (a–d and f) Cross-sections of aortic root from control mice (n=14) and 3-MA-treated mice (n=16) stained for T cells (CD3), macrophages (MOMA-2) and smooth muscle cells (αSMC-Actin). Sirius red staining was used to detect collagen fibers. TUNEL staining was used to detect apoptotic cells. Scale bar, 100 μm. (e) Analysis of vulnerability index of control mice (n=14) and 3-MA-treated mice (n=16). Data are mean±S.D. **P<0.01, ***P<0.001, unpaired two-tailed Student’s t-test

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