Figure 6 | Cell Death & Disease

Figure 6

From: Japanese encephalitis virus induces human neural stem/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress

Figure 6

JEV infection promotes ER stress and caspase activation in human neural progenitor cells (hNPCs). (a) Multipotent progenitor cells isolated from human foetus were infected with JEV for 72 h. Cells exhibit cytopathic effects post infection (scale bar −50 μm). (b) The cells exhibited elevated caspase expression along with cytochrome C release manifesting the onset of apoptosis in hNPCs (densitometry data not shown). (c) Histogram of q-PCR represents relative fold change of detected proteins (mass spectrometry) in hNPCs. (d) Co-localization of GRP78, PHB and hnRNPC were visualized in these cells post 72 h of JEV infection (scale bar −20 μm) (complete ICC image is given in Supplementary Figure S9) (*P<0.05, #P<0.01, ##P<0.001). Data are representative of three independent experiments (mean±S.D.)

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