Figure 1
From: Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis
Bcl-3 expression is associated with the metastasis of breast cancer. (a) Expression of Bcl-3 in human breast cancer clinical specimens using the TCGA BRCA dataset. (b) Western blot analysis of Bcl-3 in a panel of breast cancer cell lines. (c) The metastasis-free survival curve for breast cancer patients with low (n=58, blue curve) versus high (n=58, red curve) Bcl-3 mRNA expression. (d) The metastasis-free survival curve for ER- breast cancer patients with low (n=41, blue curve) versus high (n=34, red curve) Bcl-3 mRNA expression. (e) The metastasis-free survival curve for ER- PR- breast cancer patients with low (n=31, blue curve) versus high (n=22, red curve) Bcl-3 mRNA expression. The patients were dichotomized on the basis of the mean value of Bcl-3 mRNA expression, and their survival curves were later analyzed
