Figure 1
From: Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
Minor impact of CD19-Cre-mediated loss of one or both alleles of Mcl-1 in B-lymphoid cells on pre-B/B-cell lymphoma development in Eμ-Myc mice. (a) Kaplan–Meier survival curves comparing survival of Eμ-Myc (median 91 days), Eμ-Myc;CD19-Cre (117 days), Eμ-Myc;CD19-Cre;Mcl-1fl/+ (130 days) and Eμ-Myc;CD19-Cre;Mcl-1fl/fl mice (123 days). Eμ-Myc versus Eμ-Myc;CD19-Cre P=0.069; Eμ-Myc;CD19-Cre versus Eμ-Myc;CD19-Cre;Mcl-1fl/+ P=0.16; Eμ-Myc;CD19-Cre versus Eμ-Myc;CD19-Cre;Mcl-1fl/fl P=0.16). (b) Lymphoma burden in sick Eμ-Myc, Eμ-Myc;CD19-Cre, Eμ-Myc;CD19-Cre;Mcl-1fl/+and Eμ-Myc;CD19-Cre;Mcl-1fl/flmice. No significant differences were observed, compared with sick Eμ-Myc;CD19-Cre mice, in the weights of the spleen or lymph nodes, respectively. (c) Peripheral blood analysis of sick, lymphoma-burdened compound mutant mice using an ADVIA counter. Eμ-Myc;CD19-Cre versus Eμ-Myc;CD19-Cre;Mcl-1fl/+ display no significant changes; Eμ-Myc;CD19-Cre versus Eμ-Myc;CD19-Cre;Mcl-1fl/fl: P*lymphocytes=0.0172)
