Figure 4
From: Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
Rag1-Cre-mediated deletion of one allele of Mcl-1 greatly delays lymphoma development in Eμ-Myc mice. (a) Kaplan–Meier animal survival curves comparing Eμ-Myc, Eμ-Myc;Rag1-Cre and Eμ-Myc;Rag1-Cre;Mcl-1fl/+ mice. Eμ-Myc;Rag1-Cre versus Eμ-Myc;Rag1-Cre;Mcl-1fl/+; Mantle–Cox Log-rank test P*=0.0030). Median onset of pre-B/B-cell lymphoma: Eμ-Myc: 91 days; Eμ-Myc;Rag1-Cre: 129 days, Eμ-Myc;Rag1-Cre;Mcl-1fl/+=346 days. (b) Lymphoma burden (spleen and lymph node weights) at autopsy in sick mice of indicated genotypes. A significant difference was observed in lymph node weights (P*=0.0307) between sick Eμ-Myc;Rag1-Cre and Eμ-Myc;Rag1-Cre;Mcl-1fl/+mice. (c) The numbers of lymphoid cells, erythrocytes and thrombocytes in the peripheral blood of lymphoma-burdened mice of the indicated genotypes were determined at autopsy using the ADVIA counter. Eμ-MycRag-1-Cre versus Eμ-Myc;Rag-1-Cre;Mcl-1fl/+: P*lymph=0.0464)
