Figure 5 | Cell Death & Disease

Figure 5

From: Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

Figure 5

Lymphomas from Eμ-Myc;Rag-1-Cre;Mcl-1fl/+ mice are selected against loss of their Mcl-1fl allele. (a) Flow cytometric analysis of hCD4 reporter expression (reflecting Mcl-1fl recombination) on lymphoma cells from Eμ-Myc (control), Eμ-Myc;Rag-1-Cre and Eμ-Myc;Rag-1-Cre;Mcl-1fl/+ mice. (b) Flow cytometric analysis of hCD4 reporter expression on normal B-lymphoid cells (gated as B220+) from 3–4-week-old Rag-1-Cre; Rag1-Cre;Mcl-1fl/+ and Rag1-Cre;Mcl-1fl/fl mice

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