Figure 6
From: Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2
Models for the STAT5 phosphorylation-induced signal transduction through NPM1 protein and the potential physiological and pathological significance of cytokine-induced STAT-NPM1 signal pathways. (a) Schematic representation of the mechanism as well as functional relevance of the signalings activated by STAT5 phosphorylation. The signal pathways identified in the present study are indicated in orange, whereas the previously known pathways in black. (b) Schematic representation of our proposed STAT–NPM1 axis (STAT5–NPM1 signaling in orange, STAT3-NPM1 signaling in black) and its potential functions in biological activities and tumorigenesis (in blue)
