Figure 7 | Cell Death & Disease

Figure 7

From: Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

Figure 7

Proposed model describing the mechanism of autophagy activation and lipid catabolism by HY-SDT. ROS generated by ultrasound-activated HY are the key regulator for TFEB translocation from lysosome to nucleus to bind corresponding DNA sequences, which triggers autophagy activation and lysosome regeneration. Then the LDs derived from the engulfed ox-LDL via CD36 and SR-A are degraded to free fatty acid by autophagy activation. Moreover, TFEB nuclear translocation enhances ABCA1 expression to promote free fatty acid efflux, meanwhile decreases the expression levels of CD36 and SR-A to inhibit lipid uptake. Therefore, HY-SDT displays an efficient treatment for decreasing the lipid content of macrophage

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