Figure 2
From: Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes
TNTs facilitate intercellular transfer of lipophilic cytosolic components as well as proteins, mitochondria vesicles between SCs. (a) SCs isolated from EGFP/RFP transgenic rats expressing formed TNTs which readily transmitted the EGFP or RFP between cells. TNTs also transfer mitochondria as well. (b) TNTs of co-cultured EGFP-SCs and RFP-SCs transmitted proteins via bidirectional transfer by time-lapse imaging. Selected frames of a video sequence (Supplementary Movies S2) are shown. (c) SCs stained with either green (DiO) or red (DiI) dyes formed TNTs, which transmitted lipophilic components when mixed. The arrow and arrowhead indicate the TNTs and transferred vesicles/ proteins, respectively. Scale bars: 20 μm
