Figure 6
From: Lack of collagen XV is protective after ischemic stroke in mice
rtPA fails to reduce stroke-induced increases of IL-6 and CCL2 protein levels in the ischemic cortex of ColXV KO mice. IL-6 (a), CCL2 (b), TNF-α (c) and IFN-γ (d) protein levels at 3 days post injury in the contralateral (CL, black bars) and ipsilateral (IL, white bars) cortices of sham-operated and injured WT and ColXV KO mice thrombolysed or not with rtPA 20 min after TE stroke. Values plotted are mean±S.E.M. Kruskal–Wallis: P>0.05 for TNF-α and IFN-γ, P<0.0001 for IL-6 and CCL2. Mann–Whitney U-tests: *P<0.05, **P<0.01 compared to the contralateral hemisphere, #P<0.05 compared to the ipsilateral cortex of saline TE WT; N = 4-5 per group
