Figure 6 | Cell Death & Disease

Figure 6

From: NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

Figure 6

Nlrp3 knock out protects mice from radiation-induced death and Caspase-1 activation. (a) Survival curve: a group of 9.5 Gy radiated Nlrp3−/− mice (Nlrp3−/− +9.5 Gy, n=22) were monitored for 30 days in comparison with a group of 9.5 Gy radiated WT mice (WT+9.5 Gy, n=25), Log-rank (Mantel-Cox) test P=0.0175. (b–f) Western Blot and band intensity analysis of NLRP3-related proteins. The results are representative of three independent experiments. (g) ELISA analysis of serum IL-1β. Bars represent mean±S.E.M. (n=6–8). *P<0.05, **P<0.01 versus 0 Gy WT group; #P<0.05, ##P<0.01

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