Figure 8
From: REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival
Inhibition of REP1 enhances the anti-tumor effect of 5-FU. (a) Schematic representation of the therapy regimen in mice implanted with HCT116 colon cancer cells. Nude mice were inoculated subcutaneously with 1 × 106 HCT116 cells per mouse. Ten days following tumor challenge, siRNA CNP targeting GFP or REP1 (7 ug/mouse) was injected intravenously, twice for 2 consecutive days. Chitosan hydrogels loaded with 5-FU (0.1 mg/kg) were administered intratumorally at day 14. (b) Tumor growth in mice inoculated with HCT116 treated with the indicated reagents (five mice/group). (c) Tumor mass in mice at 23 days after challenge. Error bars represent S.D. from the mean. *P<0.01, **P<0.001
