Figure 1 | Cell Death & Disease

Figure 1

From: Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization

Figure 1

Genetic separation of cell death and thermal allodynia. (a) Schematic of canonical cell death pathway in Drosophila. (b) Larval epidermal staining 24 h after UV irradiation. Anti-Fasciclin-3 antibody (membranes, green) and TUNEL labeling (apoptotic cells, red) were used. Bar, 50 μm (c and d) Measurement of UV-induced thermal allodynia at 38 °C, 24 h after UV irradiation. Larval behavior was categorized as ‘no withdrawal’ (white), ‘slow withdrawal’ (gray, response between 6 and 20 s), or ‘fast withdrawal’ (black, response≤5 s) in this and other figures n=3 sets of 30 larvae, error bars represent S.E.M, and *P<0.05 for this and all subsequent figures. (e) Table of relevant genotypes that show or do not show epidermal cell death and UV-induced thermal allodynia

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