Figure 3

Downstream mediators of TNFR during thermal allodynia. (a) Thermal allodynia 24 h after UV irradiation. UAS-RNAi transgenes are indicated. (b) Thermal allodynia 24 h after UV irradiation in indicated mutants. (c) TNF/Eiger-induced genetic thermal allodynia on expression of the indicated RNAi transgenes. (d) Schematic model of TNF/TNFR signal transduction relevant to nociceptive sensitization