Figure 4 | Cell Death & Disease

Figure 4

From: Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization

Figure 4

Dronc activates TNF signaling by regulating active TNF ligand production. (a) Schematic of TNF/Dronc activation experiments. A58-Gal4-mediated transgene expression was controlled by tub-Gal80ts. (b) Epidermal staining of indicated genotypes. Anti-Fasciclin-3 antibody (membranes, green) and TUNEL labeling (apoptotic cells, red) were used. Bar, 50 μm. (c) Behavioral responses to 38 °C upon overexpression of Dronc with the expression of UAS-TNF/EigerRNAi and UAS-p35. (d) Thermal allodynia when full-length and soluble TNF/Eiger were overexpressed in the epidermis with or without the expression of an RNAi transgene targeting Dronc

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