Figure 7
From: CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells
The model shows CRB3-mediated regulation of the Hippo pathway. CRB3 interacts with Kibra to stabilize Kibra expression, which induces YAP phosphorylation and leads to YAP retaining in the cytoplasm. The Hippo pathway is activated (Hippo on), the expressions of YAP target genes are inhibited, cell proliferation is decreased and cell apoptosis is increased. When CRB3 expression is low, the Hippo pathway is inactivated (Hippo off), inducing the expressions of YAP target genes, increasing cell proliferation and decreasing cell apoptosis. TFs, transcription factors
