Figure 1 | Cell Death & Disease

Figure 1

From: Tsc1 expression by dendritic cells is required to preserve T-cell homeostasis and response

Figure 1

Tsc1 in DCs prevents the development of lymphoproliferative disorder. (a) Tsc1 protein was depleted in splenic DCs from CD11cCreTsc1f/f mice, determined by western blotting. (b) Total cell numbers in the spleen (Spl) and lymph nodes (LNs) from mice at different ages (n=4). (c) The numbers of different cell populations in the spleen and lymph nodes of 6-month-old mice (n=4). Myeloid cells included macrophages, neutrophils and monocytes. (d) Body weight of Tsc1f/f and CD11cCreTsc1f/f male mice of different ages (n=6). (e) Concentrations of serum IgG1, IgA, IgM and IgE in 6-month-old mice (n=6). All mice analyzed were 6 week old, unless otherwise specified. *P<0.05, **P<0.01; error bars represent S.D.; all data are representative of at least three independent experiments

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