Figure 1 | Cell Death & Disease

Figure 1

From: miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma

Figure 1

Increased expression of miR-141 was negatively correlated with BRD7 and patients’ survival in human NPC. (a) BRD7 protein expression was analyzed by IHC (c, upper panel). (b) miR-141 expression was analyzed by ISH (c, lower panel). Box diagram of BRD7 and miR-141 expression in NPC (Tumor) (N=104) and non-cancerous nasopharyngeal control (Normal) (N=56) tissues, respectively. The whiskers represent the minimum and maximum values for each group. (c) Original magnification, × 200; the size bars represent 25 μm. (d–f) Kaplan–Meier analysis to plot the overall survival (OS) curve of 60 NPC patients by expression of BRD7 and miR-141. Clinicopathological characteristics and statistical significance were assessed using the log-rank test. Kaplan–Meier curves showed worse survival rates in NPC patients with low BRD7 protein expression and high miR-141 expression compared with the related controls, respectively. ***P<0.001

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