Figure 2 | Cell Death & Disease

Figure 2

From: Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach

Figure 2

High levels of Caspase-3/-7 activity in the serum are indicative of PD in metastasised colorectal carcinoma patients (a). In a cohort of 30 metastatic CRC patients, Caspase-3/-7 activity levels in the serum were evaluated at baseline (before therapy) according to their treatment response following the first cycle of CT. PD (N=7) was associated with higher Caspase-3/-7 activity compared with SD (N=14) and partial response (PR; N=9). (b) Patients who displayed PD revealed significantly higher levels of Caspase-3/-7 activity in their serum when compared with patients who displayed SD or partial tumour regression at day 14 following commencement of therapy. (c) Caspase-3/-7 activity levels in these patients could predict PD at day 14 with a sensitivity of 86% and a specificity of 78%. *P<0.05

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