Table 2 List of differentially expressed genes in mammary glands of Wt and KO mice

From: Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

Gene	Full name	CWT *versus* CKO	CWT *versus* DWT	CKO *versus* DKO	DWT *versus* DKO	Function
GABARAP	Gamma-aminobutyric acid receptor-associated protein	−4.05^a	0.2	0.09	−4.16^a	Autophagy
Xaf1	XIAP-associated factor 1	3.25^a	0.22	0.36	3.39^a	Apoptosis
Xiap	X-linked inhibitor of apoptosis	0.51	0.86^a	0.05	−0.31	Apoptosis
Bid	BH3 interacting domain death agonist	0.16	0.53	0.76^a	0.39	Apoptosis
Apaf1	Apoptotic peptidase activating factor 1	−0.33	0.08	0.59^a	0.18	Apoptosis
Bax	BCL2-associated X protein	0.03	1.79^a	2.03^a	0.27	Apoptosis
Tnfrsf10b	Tumor necrosis factor receptor superfamily, member 10b	−0.02	0.62	0.89^a	0.25	Cell death
Ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase1	0.24	0.29	0.53^a	0.48	Cell death
Siva1	Apoptosis-inducing factor	0.08	1.3^a	1.79^a	0.57	Apoptosis
Stmn4	Stathmin-like 4	−0.01	−0.51	−1.14^a	−0.65	Microtubule destabilizer
Il1r1	Interleukin 1 receptor, type I	−0.41	0.08	0.95^a	0.45	Cytokine receptor
Cdkn1a	Cyclin-dependent kinase inhibitor 1A (P21)	−0.1	3.08^a	3.73^a	0.55	Cell cycle control
Cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18)	−0.16	0.58	0.86^a	0.12	Cell cycle control
Rbx1	Ring-box 1	0.17	0.49^a	0.3	−0.02	Cell cycle control
Cdc7	Cell division cycle 7	0.29	0.5^a	0.23	0.02	Cell cycle control
Cdk1	Cyclin-dependent kinase 1	0.77	1.06^a	0.35	0.07	Cell cycle control
Tgfb3	Transforming growth factor, beta 3	−0.19	−0.51	−0.86^a	−0.55	DNA replication
NF-κB1	Nuclear factor of kappa light polypeptide gene enhancer in B-cell 1	0.34	0.71^a	0.6	0.23	Transcription factor
Smad2	SMAD family member 2	0.42	0.67^a	0.38	0.13	Transcription factor
E2f1	E2F transcription factor 1	−0.22	−0.9^a	−0.62^a	0.07	Transcription factor
E2f4	E2F transcription factor 4	0.71	1.24^a	0.76	0.23	Transcription factor
Tfdp2	Transcription factor Dp 2	0.17	0.68^a	0.47	−0.04	Transcription factor
GABARAPL2	GABARAP-like 2	0.09	0.65^a	0.62^a	0.06	Autophagy
Atg12	Autophagy-related 12	−0.02	0.53^a	0.62^a	0.07	Autophagy
Prkaa1	Protein kinase, AMP-activated, alpha 1 catalytic subunit	0.2	0.79^a	0.7^a	0.11	Autophagy
Atg3	Autophagy-related 3	0.1	0.79^a	1.08^a	0.4	Autophagy
Atg4b	Autophagy-related 4B, cysteine peptidase	−0.57	−0.65^a	−0.15	−0.07	Autophagy
Atg5	Autophagy-related 5	0.33	0.5^a	0.28	0.11	Autophagy

Abbreviations: CKO, control (vehicle-treated) GABARAP KO (n=3); CWT, control (vehicle-treated) wild-type (n=3); DKO, DMBA-treated GABARAP KO (n=6); DWT, DMBA-treated wild-type (n=6). The values in table represent the logarithmic fold change for each gene
^aSignificant expression difference between two groups (P≤0.05) calculated by moderated t-statistic

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Table 2 List of differentially expressed genes in mammary glands of Wt and KO mice

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