Figure 4 | Cell Death & Disease

Figure 4

From: Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation

Figure 4

Gpx1 deficiency reduced the influx of CD4+ T cells and macrophages, and inhibits T-cell responses in the liver of mice. (a) Flow-cytometry analysis showed that Con A-induced MNCs are markedly decreased in the liver of Gpx1 KO mice. n=8 per group; means±S.E.M., *P<0.05, WT mice with Con A administration versus Gpx1 KO mice with Con A administration. (b) Immunohistochemistry of infiltrated immune cells such as CD4+ T cells and macrophages (F4/80) in the liver of WT and Gpx1 KO mice with Con A administration or without. (c) Immunoblots of PLCγ and IκB phosphorylation in the liver of WT and Gpx1 KO mice with Con A administration or without

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