Figure 2 | Cell Death & Disease

Figure 2

From: Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy

Figure 2

Hipk2 siRNA decreases H2AX phosphorylation but increases cisplatin toxicity in p53-negative Saos2 osteosarcoma cells. (a) Flow cytometry assay of H2AX phosphorylation of Saos2 osteosarcoma cells following a treatment with 25 μM CDDP for 28 h after a reverse transfection of a non-targeting siRNA (line) or Hipk2 siRNA (dots). (b) Comparison of cytotoxicity following a 25 μM treatment of CDDP for 72 h in Saos2 osteosarcoma cells with or without a transfection of Hipk2 siRNA

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