Figure 6
From: Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
BRG1 KD promotes senescence and inhibits cell proliferation in vivo. (a) Tumor size measured as methods and material, and the tumor growth curve is shown. (b) All mice were killed 2 weeks after injection and the tumors were collected and shown. Box plot shows the distribution of tumor weight from sh-BRG1 versus sh-Con group (n=10, mean±S.D.). (c) Immunohistochemical analysis of BRG1, SIRT1, p21, and Ki-67 in tumor sections (scale bar: 50 μm). (d) HE staining and IHC staining of indicated protein in xenograft. *P<0.05
