Figure 8

Proposed model of the effect of MFHAS1 ubiquitylation on the MAPK pathway during macrophage polarization. MFHAS1 modification, that is, ubiquitylation by praja2, activates the TLR2/JNK/p38/NF-κB pathway, resulting in M1 macrophage polarization and M2 to M1 macrophage transformation