Figure 5
From: Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Effects of interrupting salusin-β on body weight (BW), heart weight (HW), fast blood glucose and salusin-β expression levels in rats with diabetes (DM). Intravenous injection of adenoviral vectors encoding salusin-β shRNA (Ad-Salusin-shRNA, 2.0 × 1010 plaque-forming units) or scramble shRNA (Ad-Scr-shRNA) were carried out and repeated for 2 weeks in rats. The measurements were made 4 weeks after the first adenovirus transfer. (a) BW, HW and HW/BW. (b) Fast blood glucose. (c) Plasma salusin-β levels. (d) Salusin-β mRNA and protein expression in myocardium. (e) Immunofluorescence staining for salusin-β in myocardium. Values are mean±S.E.M. *P<0.05 versus Ctrl; †P<0.05 versus DM; ‡P<0.05 versus DM/Ad-Scr-shRNA. n=6
