Figure 3
From: Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice
Rnf138-knockout impairs testis development. (a) Testes harvested from Rnf138fl/fl and Rnf138−/− at 7 weeks of age. (b) Testis/body weight ratio of Rnf138fl/fl and Rnf138−/− during weeks 1 to 7 (n=3). (c and d) The diameter and thickness of seminiferous tubules (n=40) in Rnf138fl/fl and Rnf138−/− during weeks 1 to 7. (e) TUNEL assay to detect apoptotic cells in the testes of Rnf138fl/fl and Rnf138−/− mice at 6 weeks of age. (f) Quantification and comparison of apoptotic cells in the seminiferous tubules between the control and Rnf138−/− at 6 weeks (n=3). Values are mean±S.D. ***P<0.001; NS, no significance
