Figure 1
From: Molecular insights of Gas6/TAM in cancer development and therapy
The structures of Gas6 and TAM. (a) The Gla domain is at the N terminus and is followed by a loop that is maintained by a disulphide bridge. Next to the loop are four EGF-like domains. At the C terminus, Gas6 contains an SHBG-like domain comprising two subdomains with similar structures to the globular motifs of LamG. (b) The TAM receptors, Axl, Mer and Tyro3, are RTKs that have an intracellular tyrosine kinase domain. The extracellular domains contain a combination of two N-terminal immunoglobulin (Ig)-like domains and two fibronectin type-III (FNIII) repeats. EGF, epidermal growth factor; FNIII, fibronectin type-III; Ig, immunoglobulin; LamG, globular modules of laminin G; SHBG, sex hormone-binding globulin
