Figure 1 | Cell Death & Disease

Figure 1

From: Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial–mesenchymal transition and metastasis

Figure 1

Pigment epithelium-derived factor (PEDF) expression is diminished in human nasopharyngeal carcinoma (NPC) cells, associated with clinicopathological and epithelial–mesenchymal transition (EMT) features. (a) The representative area of nasopharynx epithelial tissues (NET) or NPC. NPC 1, weak PEDF expression. NPC 2, negative PEDF expression. (b) Quantitative analysis of staining intensity for PEDF in various tissues. (c) The expression of PEDF, E-cadherin and Vimentin in a cohort of NET biopsy samples and NPC samples using immunohistochemistry assay. (d and e) PEDF significantly correlates with E-cadherin and Vimentin in a cohort of NET biopsy samples and NPC samples. (f and g) Real-time PCR and western blot (WB) analysis of the expression levels of PEDF in a series of human NPC cell lines, normalized to β-actin levels. Bars correspond to mean±standard deviation (S.D.), *P<0.05

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