Figure 1 | Cell Death & Disease

Figure 1

From: Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway

Figure 1

Expression of SLC12A5 mRNA and protein in human primary BUC surgical specimens as evaluated by qRT-PCR, western blot and IHC. (a) The mRNA expression of SLC12A5 is upregulated in 10 BUC tissues than in matched adjacent noncancerous tissues, analyzed by qRT-PCR analysis. (b) Representative results of expression of SLC12A5 protein in 10 paired BUC tissues and matched adjacent noncancerous tissues (T, BUC tissues; N, matched noncancerous tissues). (c–f) IHC analysis of SLC12A5 protein expression in primary BUC surgical specimens (× 400). (c) Low expression of SLC12A5 was observed in a BUC tissue (case 18), in which <20% of tumor cells demonstrated staining of SLC12A5. (d) Another BUC (case 89) tissue showed low expression of SLC12A5, in which 20–50% of tumor cells demonstrated staining of SLC12A5. (e) High expression of SLC12A5 was observed in a BUC case (case 8). (f) Strong SLC12A5 IHC signaling was detected in the BUC cells (case 26)

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