Figure 2 | Cell Death & Disease

Figure 2

From: Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway

Figure 2

Kaplan–Meier survival curves for BUC patients after radical cystectomy according to SLC12A5 expression. (a) Significantly improved survival was observed in all BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001). (b) Significantly improved survival was observed in low-grade BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P=0.020). (c) Significantly improved survival was observed in high-grade BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001). (d) Probability of survival of pT1 patients with BUC (P=0.293). (e) Significantly improved survival was observed in pT2 BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001). (f) Significantly improved survival was observed in pT3/pT4 BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001). (g) Significantly improved survival was observed in pN− BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001). (h) Significantly improved survival was observed in pN+ BUC patients whose tumors exhibited low SLC12A5 expression versus those whose tumors exhibited high SLC12A5 expression (P<0.001)

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