Figure 5 | Cell Death & Disease

Figure 5

From: Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway

Figure 5

SLC12A5 promotes migration and invasion of BUC cells by enhancing MMP-7 expression. (a) Western blot of SLC12A5, MMP-7 and TIMP-1 from BUC cells transfected with the SLC12A5 ShRNA or control ShRNA. MMP-7 expression was downregulated independent of TIMP-1 in SLC12A5 knockdown BUC cells. (b) Western blot of SLC12A5 and MMP-7 from BUC cells transfected with the control ShRNA, SLC12A5 ShRNA or co-treated with overexpression of MMP-7 (MMP-7OE). (c and d) The reduction of migration and invasion regulated by SLC12A5 knockdown in BUC cells was rescued by overexpression of MMP-7. All the experiments were carried out in triplicate. Histograms represent means±S.D.; *P<0.01

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