Figure 7
ADAR1 overexpression triggers enhanced apoptosis. (a) Western blot analysis was done on U87 (left) and HepG2 (right) cancer cell lines ectopically overexpressing ADAR1 and treated with STA. The indicated protein expression was examined, with GAPDH being the internal control. (b) The STA-treated cultures from (a) were analyzed for extent of apoptosis by flow cytometry. (c) Bar graph represents quantitatively the percentages of cell death in the STA-treated cultures of control or ADAR1-overexpressing cells, showing means±S.D. of at least three independent experiments. Apoptotic levels were normalized to the Ctrl group (for statistical analyses shown in this figure: NS, not significant or P>0.05; *P<0.05; **P<0.01; ***P<0.001)
