Figure 2 | Cell Death & Disease

Figure 2

From: RETRACTED ARTICLE: Deregulated AJAP1/β-catenin/ZEB1 signaling promotes hepatocellular carcinoma carcinogenesis and metastasis

Figure 2

AJAP1 suppresses HCC cell growth in vitro and in vivo. (a) Growth curves were generated based on counts of indicated HCC cells (shCon, shAJAP1, Con, and AJAP1). (b) Results of the colony formation assay with HCC cells are shown in the upper panels. Number of foci was counted as shown in the lower panels. (c) AJAP1 knockdown increases SMMC7221 cell xenograft growth in nude mice, while AJAP1 overexpression decreases HCCLM3 cell xenograft growth in nude mice. Tumor volume and weight are shown. (d) AJAP1 and Ki-67 expression as detected by immunohistochemistry. Scale bar=25 μm. The data are expressed as mean±S.D. of three independent experiments. *P<0.05; **P<0.01; ***P<0.001

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