Figure 5
The anti-apoptotic pathway of LAT. The main domain of the LAT gene is contained in the first 1.5 kb. LAT can inhibit apoptosis by interacting with the following pathways: (a) LAT stabilizes the levels of total and phosphorylated AKT protein, which phosphorylates and inactivates the pro-apoptotic proteins Bad, Bax and caspase-9 to ultimately regulate caspase-3 activation and block apoptosis; (b) LAT cooperates with RIG-1 to promote NF-κB-dependent transcription to interfere with apoptosis and benefit cell survival; and (c) LAT substitutes for the function of c-FLIP, which is an inhibitor of caspase-8-mediated apoptosis
