Table 1 α-Herpesvirus gene or protein that negatively modulates the apoptosis pathway

LAT

Latency

Caspase-3/9, AKT, c-FLIP, NFκB

Intrinsic pathway, extrinsic pathway

^{70, 73, 76}

ICP22

Lytic, IE(α)

Caspase-3, p53, eIF-2α, viral gene

Intrinsic pathway

^{86, 88, 93}

ICP27

Lytic, IE(α)

NF-κB, JNK, p38, Bcl-2 family

Intrinsic pathway, extrinsic pathway

^{101, 106, 111}

US3

Tegument, L(γ)

Caspase-3, Bcl-2 family, NF-κB, AKT, TLR2, PAK, PDCD4

Intrinsic pathway, extrinsic pathway

^{125, 129, 132, 133, 142}

US5(gJ)

Envelope, L(γ)

Caspase-3, Caspase-8, F₀F₁ ATP synthase

Extrinsic pathway

^{85, 120}

US6(gD)

Envelope, L(γ)

NF-κB, HVEM

Extrinsic pathway

^{149, 151}

US8(gE)

Envelope, L(γ)

Bim

Intrinsic pathway

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