Figure 2 | Cell Death & Disease

Figure 2

From: Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model

Figure 2

Overexpression of EphB2 rescues decreased expressions of EphB2 and the surface expression of GluN2B-containing NMDA receptors induced by ADDLs in cultured hippocampal neurons. (a) Overexpression of EphB2 rescued the decreased total and surface expression of EphB2 induced by ADDLs (n=3 in each group). (b) Overexpression of EphB2 rescued the decreased surface expression of GluN2B. The reduced pY1472 was improved as well (p-GluN2B: n=5 in each group, S-GluN2B: n=3 in each group). (c) Overexpression of EphB2 rescued the decreased surface expression of GluN1 (n=4 in each group). *P<0.05, **P<0.01 versus corresponding control group; #P<0.05, ##P<0.01 versus corresponding ADDLs group. Data are presented as mean±S.E.M.

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