Figure 4 | Cell Death & Disease

Figure 4

From: Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model

Figure 4

Overexpression of EphB2 in hippocampus ameliorates anxiety- or depression-like behaviors in APP/PS1 transgenic mice. (a and b) Overexpression of EphB2 ameliorated anxiety-like behavior. APP/PS1 transgenic mice showed an anxiety-like behavior. Lenti-EphB2-treated but not Lenti-empty-treated APP/PS1 transgenic mice spent less time on the latency (a) and dark area (b) (n=10 in each group). (c) APP/PS1 transgenic mice showed a depression-like behavior. Lenti-EphB2-treated but not Lenti-empty-treated APP/PS1 transgenic mice spent less time on floating time (n=10 in each group). *P<0.05, **P<0.01 versus Lenti-empty-treated WT group; #P<0.05, ##P<0.01 versus Lenti-empty-treated APP group. Data are presented as mean±S.E.M.

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