Figure 6 | Cell Death & Disease

Figure 6

From: Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model

Figure 6

Overexpression of EphB2 in hippocampus rescues the GluN2B-containing NMDA receptors trafficking in APP/PS1 transgenic mice. (a) Overexpression of EphB2 significantly rescued the reduced phosphorylated level of GluN2B at pY1472 in APP/PS1 transgenic mice (n=4 in each group). (b) Overexpression of EphB2 significantly rescued the reduced surface expression of GluN2B in APP/PS1 transgenic mice (n=4 in each group). (c) Overexpression of EphB2 significantly rescued the reduced surface expression of GluN1 in APP/PS1 transgenic mice (n=4 in each group). (d) Overexpression of EphB2 had no effect on the total expression of GluN1 in APP/PS1 transgenic mice (n=4 in each group). (e and f) Overexpression of EphB2 had no effect on both the total (e) and surface (f) expressions of GluN2A in APP/PS1 transgenic mice (n=4 in each group). *P<0.05, **P<0.01 versus the Lenti-empty-treated WT group; #P<0.05, ##P<0.01 versus the Lenti-empty-treated APP group. Data are presented as mean±S.E.M.

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