Figure 2 | Cell Death & Disease

Figure 2

From: miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2

Figure 2

Genetic deletion of miR-146a alleviates cartilage destruction in instability-induced OA models. (a and b) Safranin O and fast green staining (a) or OARSI scores (b) of knee joint cartilage sections in WT and miR-146a KO mice collected at 4 weeks after DMM (WT, n=10; miR-146a KO, n=14) or sham surgery (WT, n=6; miR-146a KO, n=8). F, femur; T, tibia. Scale bars, 100 μm. (c-e) Immunohistochemical staining and quantification of the percentage of Col10a1 and Mmp13-positive chondrocytes in articular cartilage of sham-operated mice (WT, n=6; miR-146a KO, n=8) and DMM mice (WT, n=10; miR-146a KO, n=14). Scale bars, 100 μm.Data are mean±S.D. *P<0.05, **P<0.01 (Mann–Whitney test) in b, d and e. NS, not significant between the indicated groups

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