Figure 1 | Cell Death & Disease

Figure 1

From: TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination

Figure 1

TRIM45 expression is reduced in glioma tissues. (a) TRIM45 mRNA levels in normal brain tissues (Normal) and glioma tissues (Tumor) were determined by real-time PCR. (b) Representative images from immunoblot analyses of TRIM45 levels in normal brain tissues (N) and glioma tissues (T). Protein expression levels were normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) levels. (c) Comparison of TRIM45 mRNA levels among gliomas of different pathological grades. (d) Representative images from immunohistochemistry (IHC) assays of paraffin-embedded specimens. Scale bars: 100 μm. Data in panels (a and c) are presented as the mean±S.D. ***P<0.001

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