Figure 1 | Cell Death & Disease

Figure 1

From: Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

Figure 1

Madecassic acid was the active form of madecassoside in ameliorating DSS-induced colitis in mice. Mice were fed with 2.5% DSS for 7 days and then given normal water for an additional 3 days. Madecassoside (50 mg/kg), asiaticoside (50 mg/kg), madecassic acid (25 mg/kg), asiatic acid (25 mg/kg) and cyclosporin A (25 mg/kg) were orally administered for consecutive 10 days. (a) Chemical structures of madecassoside, asiaticoside, madecassic acid and asiatic acid. (b) DAI. (c) The colon length of each group at day 10. (d) The activity of MPO in the colons. (e) The epithelial damage, inflammatory cell infiltration and crypt lesions were evaluated by H&E staining. (f) Mice were rectally administered test compounds for 10 days. DAI. (g) Colon length. (h) MPO activity. (i) H&E staining. The data were expressed as means±S.E.M., n=5–8. ##P<0.01 versus normal group; *P<0.05, **P<0.01 versus DSS group

Back to article page