Table 1 Genes contribute to polyploidy
From: Hepatocyte polyploidization and its association with pathophysiological processes
Gene symbol | Gene function | Genetic modification | Effect on liver polyploidization | References |
|---|---|---|---|---|
E2f7/8 | Cell cycle transcription factor | Deletion | Impair polyploidization | |
Ccne1 | Cell cycle, G1/S transition | Deletion | Impair polyploidization | |
E2f1/2/3 | Cell cycle transcription factor | Deletion | Promote polyploidization | |
Trp53 | Cell cycle factor, tumor supressor | Deletion | Promote polyploidization | |
p21 | Cell cycle factor | Deletion | Promote polyploidization | |
Rb | Cell cycle, mitosis | Deletion | Promote polyploidization | |
Cdk1 | Cell cycle, mitosis | Deletion | Promote polyploidization | |
Ccne2 | Cell cycle, G1/S transition | Deletion | Promote polyploidization | |
Skp2 | Cell cycle | Deletion | Promote polyploidization | |
Ssu72 | Cell cycle | Deletion | Promote polyploidization | |
ERCC1 | DNA repair | Deletion | Promote polyploidization | |
Survivin | Cell cycle, mitosis | Deletion | Promote polyploidization | |
miR-122 | Proliferation | Overexprssion | Promote polyploidization |
