Figure 3 | Cell Death & Disease

Figure 3

From: Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication

Figure 3

LGP2 suppresses several cytokines expression during FMDV infection. PK-15 cells were transfected with Myc-vector or Myc-LGP2 plasmids, and transfected cells were infected with FMDV at 24 hpt. Cytokine expression levels in the cell lysates was detected at 18 hpi using porcine cytokine array kits (RayBiotech). (a) Downregulation of cytokines was greater in LGP2 overexpressing cells than vector-transfected cells after FMDV infection. (b) Upregulation of cytokines was greater in LGP2-overexpressing than vector-transfected cells after FMDV infection. (c) qPCR analysis of mRNA abundance of six determined cytokines.

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