Figure 4 | Cell Death & Disease

Figure 4

From: Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis

Figure 4

Contribution of ROS generation and preferential uptake in D112 selectivity. (a) D112 selectively induced apoptosis in cancer cells. Phosphatidylserine exposure was quantitated by flow cytometry. (b) D112 induced high level of ROS in cancer cells. Normalized ROS level was MFI of (treated cells/untreated cells). (c) Selective intracellular D112 uptake. White and green arrows indicate representative MCF-10A and SK-BR-3 cells. Scale bar, 20 μm. (d) Quantitation of D112 uptake from media. Normalized D112 intensity was displayed as the ratio of D112 fluorescence in (media that contained cells/media without cells). All values are mean±S.D. of three independent experiments. *P<0.05

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