Figure 7 | Cell Death & Disease

Figure 7

From: Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway

Figure 7

Schematic diagram on the mechanism of CaSR cardioprotection via attenuating high glucose-induced myocardial energy metabolism disorder. The downregulation of CaSR expression in cardiomyocytes induced by HG have a crucial role in myocardial energy metabolism disorder. The decreased CaSR expression causes upregulation of gp78 expression and activation of the ubiquitin proteasome system, which then degrades Mfn1, Mfn2, respiratory chain complex protein, Cx43, N-cadherin and β-catenin protein, and results in the decrease of ATP synthesis and the increase of ATP leakage through damaged gap junction. Therefore, CaSR agonists are expected to be a new target for the prevention and treatment of DCM

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