Figure 6 | Cell Death & Disease

Figure 6

From: Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

Figure 6

Possible model of Notch signaling transduction in regulation of MSC in vitro aging. Activations of Notch signaling by Jagged1 (JAG1) in MSC sheet culture stimulates cell proliferation and inhibits aging. Notch signaling includes sequential stimulation of a signaling cascade involving Notch intracellular domain (NICD) and Hes1. NICD induces the expression of Hes1, which may lead to activation of Cyclin D1 (CCND1) and inhibition of p16, leading to the delay of MSC aging in cultures

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