Figure 1 | Cell Death & Disease

Figure 1

From: Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme

Figure 1

NIM811 induces ER vacuolization and paraptosis cell death in GBM cells. (a) Pan-caspase inhibitor Qvd-oph was not able to rescue cell death induced by 10 μM NIM811 at 24 h. (b) Electron microscopic images revealing the morphological structures of vacuoles, scale bar=10 μm. (c) Labeling cells with GFP-ER signal sequence of calreticulin-KDEL (1–2) and TagRFP-Leader sequence of E1 alpha pyruvate dehydrogenase (3-4) or RFP-lamp1 (5-6) indicate that the vacuoles originate from the ER. Scale bar=25 μm

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